Tyrosine Metabolism During Interferon-alpha Administration: Association with Fatigue and CSF Dopamine Concentrations

Chronic exposure to interferon (IFN)-alpha, an innate immune cytokine, produces high rates of behavioral disturbances, including depression and fatigue. These effects may be mediated by the actions of IFN-alpha on dopamine (DA) metabolism in the basal ganglia. Diminished conversion of phenylalanine...

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Hlavní autoři: Felger, Jennifer C., Li, Li, Marvar, Paul J., Woolwine, Bobbi J., Harrison, David G., Raison, Charles L., Miller, Andrew H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578984/
https://ncbi.nlm.nih.gov/pubmed/23072726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2012.10.010
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