Oral, subcutaneous, and intramuscular bioavailabilities of the antiviral nucleotide analog 9-(2-phosphonylmethoxyethyl) adenine in cynomolgus monkeys.

Intravenous, subcutaneous, intramuscular, and oral pharmacokinetics of the antiretroviral nucleotide analog [9-(2-phosphonylmethoxyethyl)adenine] (PMEA) were examined in a crossover study with four cynomolgus monkeys using 14C-labelled drug at 10 mg/kg of body weight (20 microCi/kg). Plasma radioact...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Cundy, K C, Shaw, J P, Lee, W A
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284458/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8192467/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.38.2.365
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