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Safety, Pharmacokinetics, and Antiretroviral Activity of Intravenous 9-[2-(R)-(Phosphonomethoxy)propyl]adenine, a Novel Anti-Human Immunodeficiency Virus (HIV) Therapy, in HIV-Infected Adults

9-[2-(R)-(Phosphonomethoxy)propyl]adenine (PMPA) is a nucleotide analogue with potent antiretroviral activity in vitro and in simian models. A randomized, double-blind, placebo-controlled, dose-escalation clinical trial of intravenous PMPA monotherapy was conducted in 20 human immunodeficiency virus...

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Publicado no:Antimicrob Agents Chemother
Principais autores: Deeks, Steven G., Barditch-Crovo, Patricia, Lietman, Paul S., Hwang, Frances, Cundy, Kenneth C., Rooney, James F., Hellmann, Nicholas S., Safrin, Sharon, Kahn, James O.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1998
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105837/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9736567/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.9.2380
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