Augmentation of Therapeutic Efficacy in Drug-Resistant Tumor Models Using Ceramide Coadministration in Temporal-Controlled Polymer-Blend Nanoparticle Delivery Systems

The development of multidrug resistance (MDR) is a major hindrance to cancer eradication as it renders tumors unresponsive to most chemotherapeutic treatments and is associated with cancer resurgence. This study describes a novel mechanism to overcome MDR through a polymer-blend nanoparticle platfor...

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Main Authors: van Vlerken, Lilian E., Duan, Zhenfeng, Little, Steven R., Seiden, Michael V., Amiji, Mansoor M.
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844507/
https://ncbi.nlm.nih.gov/pubmed/20143195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-010-9174-4
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