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Sodium channel selectivity filter regulates antiarrhythmic drug binding
Local anesthetic antiarrhythmic drugs block Na(+) channels and have important clinical uses. However, the molecular mechanism by which these drugs block the channel has not been established. The family of drugs is characterized by having an ionizable amino group and a hydrophobic tail. We hypothesiz...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The National Academy of Sciences of the USA
1997
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC28444/ https://ncbi.nlm.nih.gov/pubmed/9391164 |
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