MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks

PALB2 physically and functionally connects the proteins encoded by the BRCA1 and BRCA2 breast and ovarian cancer genes into a DNA-damage-response network. However, it remains unclear how these proteins associate with chromatin that contains damaged DNA. We show here that PALB2 binds directly to a co...

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Detaylı Bibliyografya
Asıl Yazarlar: Hayakawa, Tomohiro, Zhang, Fan, Hayakawa, Noriyo, Ohtani, Yasuko, Shinmyozu, Kaori, Nakayama, Jun-ichi, Andreassen, Paul R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Company of Biologists 2010
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844321/
https://ncbi.nlm.nih.gov/pubmed/20332121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.060178
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