Disruption of the K(+) Channel β-Subunit KCNE3 Reveals an Important Role in Intestinal and Tracheal Cl(−) Transport

The KCNE3 β-subunit constitutively opens outwardly rectifying KCNQ1 (Kv7.1) K(+) channels by abolishing their voltage-dependent gating. The resulting KCNQ1/KCNE3 heteromers display enhanced sensitivity to K(+) channel inhibitors like chromanol 293B. KCNE3 was also suggested to modify biophysical pro...

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Detalhes bibliográficos
Main Authors: Preston, Patricia, Wartosch, Lena, Günzel, Dorothee, Fromm, Michael, Kongsuphol, Patthara, Ousingsawat, Jiraporn, Kunzelmann, Karl, Barhanin, Jacques, Warth, Richard, Jentsch, Thomas J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844166/
https://ncbi.nlm.nih.gov/pubmed/20051516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.047829
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