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Structural Insight into the Inhibition of Human Kynurenine Aminotransferase I/Glutamine transaminase K
Human kynurenine aminotransferase I (hKAT I) catalyzes the formation of kynurenic acid, a neuroactive compound. Here, we report three high-resolution crystal structures (1.50–1.55 Å) of hKAT I that are in complex with glycerol and each of two inhibitors of hKAT I: indole-3-acetic acid (IAC) and Tris...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2844090/ https://ncbi.nlm.nih.gov/pubmed/19338303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm9000874 |
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