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Resistance to 1,25D-Induced Differentiation in Human Acute Myeloid Leukemia HL60-40AF Cells Is Associated With Reduced Transcriptional Activity and Nuclear Localization of the Vitamin D Receptor
The anti-neoplastic effects of 1,25-dihydroxyvitamin D(3) (1,25D) are well documented in numerous tumor cell systems and animal models of cancer. However, despite this pre-clinical success, the clinical use of 1,25D is currently impeded by the dose-limiting hypercalcemia, and the risk of development...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2007
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2843698/ https://ncbi.nlm.nih.gov/pubmed/17520689 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.21150 |
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