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Resistance to 1,25D-Induced Differentiation in Human Acute Myeloid Leukemia HL60-40AF Cells Is Associated With Reduced Transcriptional Activity and Nuclear Localization of the Vitamin D Receptor

The anti-neoplastic effects of 1,25-dihydroxyvitamin D(3) (1,25D) are well documented in numerous tumor cell systems and animal models of cancer. However, despite this pre-clinical success, the clinical use of 1,25D is currently impeded by the dose-limiting hypercalcemia, and the risk of development...

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Bibliografske podrobnosti
Main Authors: Garay, Edward, Donnelly, Robert, Wang, Xuening, Studzinski, George P.
Format: Artigo
Jezik:Inglês
Izdano: 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843698/
https://ncbi.nlm.nih.gov/pubmed/17520689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.21150
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