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Induction of differentiation of human leukemia cells by combinations of COX inhibitors and 1,25-dihydroxyvitamin D(3) involves Raf1 but not Erk 1/2 signaling

Differentiation therapy of cancer is being explored as a potential modality for treatment of myeloid leukemia, and derivatives of vitamin D are gaining prominence as agents for this form of therapy. Cyclooxygenase (COX) inhibitors have been reported to enhance 1,25-dihydroxyvitamin D(3) (1,25D)-indu...

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Bibliografiske detaljer
Main Authors: Jamshidi, Farnaz, Zhang, Jing, Harrison, Jonathan S., Wang, Xuening, Studzinski, George P.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843692/
https://ncbi.nlm.nih.gov/pubmed/18414055
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