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Hepatitis B Virus X Protein Impairs Hepatic Insulin Signaling Through Degradation of IRS1 and Induction of SOCS3

BACKGROUND: Hepatitis B virus (HBV) is a major cause of chronic liver diseases, and frequently results in hepatitis, cirrhosis, and ultimately hepatocellular carcinoma. The role of HCV in associations with insulin signaling has been elucidated. However, the pathogenesis of HBV-associated insulin sig...

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Detalhes bibliográficos
Main Authors: Kim, KyeongJin, Kim, Kook Hwan, Cheong, JaeHun
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843628/
https://ncbi.nlm.nih.gov/pubmed/20351777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008649
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