A Conformational Switch in the Scaffolding Protein NHERF1 Controls Autoinhibition and Complex Formation

The mammalian Na(+)/H(+) exchange regulatory factor 1 (NHERF1) is a multidomain scaffolding protein essential for regulating the intracellular trafficking and macromolecular assembly of transmembrane ion channels and receptors. NHERF1 consists of tandem PDZ-1, PDZ-2 domains that interact with the cy...

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Bibliographic Details
Main Authors: Bhattacharya, Shibani, Dai, Zhongping, Li, Jianquan, Baxter, Sabine, Callaway, David J. E., Cowburn, David, Bu, Zimei
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843244/
https://ncbi.nlm.nih.gov/pubmed/20042604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.074005
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