CDKN1C Negatively Regulates RNA Polymerase II C-terminal Domain Phosphorylation in an E2F1-dependent Manner

CDKN1C is a cyclin-dependent kinase inhibitor and is a candidate tumor suppressor gene. We previously found that the CDKN1C protein represses E2F1-driven transcription in an apparent negative feedback loop. Herein, we explore the mechanism by which CDKN1C represses transcription. We find that adenov...

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Hlavní autoři: Ma, Yihong, Chen, Lu, Wright, Gabriela M., Pillai, Smitha R., Chellappan, Srikumar P., Cress, W. Douglas
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Gene Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843230/
https://ncbi.nlm.nih.gov/pubmed/20106982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.091496
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