Nicotinic acetylcholine receptors induce c-Kit ligand/Stem Cell Factor and promote stemness in an ARRB1/ β-arrestin-1 dependent manner in NSCLC

Lung cancer remains the leading cause of cancer-related deaths worldwide. β-arrestin-1 (ARRB1), a scaffolding protein involved in the desensitization of signals arising from activated G-protein-coupled receptors (GPCRs), has been shown to play a role in invasion and proliferation of cancer cells, in...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Perumal, Deepak, Pillai, Smitha, Nguyen, Jonathan, Schaal, Courtney, Coppola, Domenico, Chellappan, Srikumar P.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2014
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4279388/
https://ncbi.nlm.nih.gov/pubmed/25401222
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