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Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase

γ-Aminobutyric acid (GABA), the major inhibitory neurotransmitter in the mammalian brain, is synthesized by two glutamate decarboxylase isoforms, GAD65 and GAD67. The separate role of the two isoforms is unknown, but differences in saturation with cofactor and subcellular localization suggest that G...

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Autors principals: Kash, Shera F., Johnson, Randall S., Tecott, Laurence H., Noebels, Jeffrey L., Mayfield, R. Dayne, Hanahan, Douglas, Baekkeskov, Steinunn
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences of the USA 1997
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC28432/
https://ncbi.nlm.nih.gov/pubmed/9391152
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