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Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase

γ-Aminobutyric acid (GABA), the major inhibitory neurotransmitter in the mammalian brain, is synthesized by two glutamate decarboxylase isoforms, GAD65 and GAD67. The separate role of the two isoforms is unknown, but differences in saturation with cofactor and subcellular localization suggest that G...

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Detalhes bibliográficos
Main Authors: Kash, Shera F., Johnson, Randall S., Tecott, Laurence H., Noebels, Jeffrey L., Mayfield, R. Dayne, Hanahan, Douglas, Baekkeskov, Steinunn
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1997
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC28432/
https://ncbi.nlm.nih.gov/pubmed/9391152
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