Virus-triggered Ubiquitination of TRAF3/6 by cIAP1/2 Is Essential for Induction of Interferon-β (IFN-β) and Cellular Antiviral Response

Viral infection causes activation of transcription factors NF-κB and IRF3, which collaborate to induce type I interferons (IFNs) and cellular antiviral response. Here we show that knockdown of the E3 ubiquitin ligases cIAP1 and cIAP2 markedly inhibited virus-triggered activation of IRF3 and NF-κB as...

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Bibliographic Details
Main Authors: Mao, Ai-Ping, Li, Shu, Zhong, Bo, Li, Ying, Yan, Jie, Li, Qi, Teng, Chengwen, Shu, Hong-Bing
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843197/
https://ncbi.nlm.nih.gov/pubmed/20097753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.071043
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