Src Kinase Phosphorylates RUNX3 at Tyrosine Residues and Localizes the Protein in the Cytoplasm

RUNX3 is a transcription factor that functions as a tumor suppressor. In some cancers, RUNX3 expression is down-regulated, usually due to promoter hypermethylation. Recently, it was found that RUNX3 can also be inactivated by the mislocalization of the protein in the cytoplasm. The molecular mechani...

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Autors principals: Goh, Yun-Mi, Cinghu, Senthilkumar, Hong, Eileen Tan Hwee, Lee, You-Soub, Kim, Jang-Hyun, Jang, Ju-Won, Li, Ying-Hui, Chi, Xin-Zi, Lee, Kyeong-Sook, Wee, Heejun, Ito, Yoshiaki, Oh, Byung-Chul, Bae, Suk-Chul
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843174/
https://ncbi.nlm.nih.gov/pubmed/20100835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.071381
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