The Runt-related transcription factor RUNX3 is a target of MDM2-mediated ubiquitination

The p14(ARF)-MDM2-p53 pathway constitutes an effective mechanism for protecting cells from oncogenic stimuli like activated Ras and Myc. Importantly, Ras activation induces p14(ARF) and often occurs earlier than p53 inactivation during cancer development. Here we show that RUNX3, a tumor suppressor...

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Hlavní autoři: Chi, Xin-Zi, Kim, Jiyeon, Lee, Yong-Hee, Lee, Jung-Won, Lee, Kyeong-Sook, Wee, Heejun, Kim, Wun-Jae, Park, Woo-Yoon, Oh, Byung-Chul, Stein, Gary S., Ito, Yoshiaki, van Wijnen, Andre J., Bae, Suk-Chul
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059505/
https://ncbi.nlm.nih.gov/pubmed/19808967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-1057
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