The Runt-related transcription factor RUNX3 is a target of MDM2-mediated ubiquitination

The p14(ARF)-MDM2-p53 pathway constitutes an effective mechanism for protecting cells from oncogenic stimuli like activated Ras and Myc. Importantly, Ras activation induces p14(ARF) and often occurs earlier than p53 inactivation during cancer development. Here we show that RUNX3, a tumor suppressor...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Chi, Xin-Zi, Kim, Jiyeon, Lee, Yong-Hee, Lee, Jung-Won, Lee, Kyeong-Sook, Wee, Heejun, Kim, Wun-Jae, Park, Woo-Yoon, Oh, Byung-Chul, Stein, Gary S., Ito, Yoshiaki, van Wijnen, Andre J., Bae, Suk-Chul
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059505/
https://ncbi.nlm.nih.gov/pubmed/19808967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-1057
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados