The Runt-related transcription factor RUNX3 is a target of MDM2-mediated ubiquitination

The p14(ARF)-MDM2-p53 pathway constitutes an effective mechanism for protecting cells from oncogenic stimuli like activated Ras and Myc. Importantly, Ras activation induces p14(ARF) and often occurs earlier than p53 inactivation during cancer development. Here we show that RUNX3, a tumor suppressor...

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Autori principali: Chi, Xin-Zi, Kim, Jiyeon, Lee, Yong-Hee, Lee, Jung-Won, Lee, Kyeong-Sook, Wee, Heejun, Kim, Wun-Jae, Park, Woo-Yoon, Oh, Byung-Chul, Stein, Gary S., Ito, Yoshiaki, van Wijnen, Andre J., Bae, Suk-Chul
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059505/
https://ncbi.nlm.nih.gov/pubmed/19808967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-1057
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