Histone Deacetylase Inhibitors Activate NF-κB in Human Leukemia Cells through an ATM/NEMO-related Pathway

Mechanisms underlying histone deacetylase inhibitor (HDACI)-mediated NF-κB activation were investigated in human leukemia cells. Exposure of U937 and other leukemia cells to LBH-589 induced reactive oxygen species (ROS) followed by single strand (XRCC1) and double strand (γ-H2AX) DNA breaks. Notably...

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Detalhes bibliográficos
Main Authors: Rosato, Roberto R., Kolla, Sarah S., Hock, Stefanie K., Almenara, Jorge A., Patel, Ankita, Amin, Sanjay, Atadja, Peter, Fisher, Paul B., Dent, Paul, Grant, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843169/
https://ncbi.nlm.nih.gov/pubmed/20065354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.095208
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