The Human Cytomegalovirus MHC Class I Homolog UL18 Inhibits LIR-1(+) but Activates LIR-1(−) NK Cells

The inhibitory leukocyte Ig-like receptor 1 (LIR-1, also known as ILT2, CD85j, or LILRB1) was identified by its high affinity for the human CMV (HCMV) MHC class I homolog gpUL18. The role of this LIR-1-gpUL18 interaction in modulating NK recognition during HCMV infection has previously not been clea...

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Main Authors: Prod’homme, Virginie, Griffin, Cora, Aicheler, Rebecca J., Wang, Eddie C. Y., McSharry, Brian P., Rickards, Carole R., Stanton, Richard J., Borysiewicz, Leszek K., López-Botet, Miguel, Wilkinson, Gavin W. G., Tomasec, Peter
Format: Artigo
Sprog:Inglês
Udgivet: 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843079/
https://ncbi.nlm.nih.gov/pubmed/17372005
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