Synthesis and antimicrobial evaluation of dirithromycin (AS-E 136; LY237216), a new macrolide antibiotic derived from erythromycin.

Dirithromycin is a 9-N-11-O-oxazine derivative which is formed by condensation of 9(S)-erythromycylamine with 2-(2-methoxyethoxy)acetaldehyde. Dirithromycin is hydrolyzed, either under acidic conditions or in vivo, to its major active metabolite, 9(S)-erythromycylamine. The antimicrobial spectrum of...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Counter, F T, Ensminger, P W, Preston, D A, Wu, C Y, Greene, J M, Felty-Duckworth, A M, Paschal, J W, Kirst, H A
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1991
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284297/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1929252/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.35.6.1116
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