Synthesis and antimicrobial evaluation of dirithromycin (AS-E 136; LY237216), a new macrolide antibiotic derived from erythromycin.

Dirithromycin is a 9-N-11-O-oxazine derivative which is formed by condensation of 9(S)-erythromycylamine with 2-(2-methoxyethoxy)acetaldehyde. Dirithromycin is hydrolyzed, either under acidic conditions or in vivo, to its major active metabolite, 9(S)-erythromycylamine. The antimicrobial spectrum of...

Täydet tiedot

Bibliografiset tiedot

Julkaisussa:	Antimicrob Agents Chemother
Päätekijät:	Counter, F T, Ensminger, P W, Preston, D A, Wu, C Y, Greene, J M, Felty-Duckworth, A M, Paschal, J W, Kirst, H A
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	American Society for Microbiology (ASM) 1991
Aiheet:	Research Article
Linkit:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284297/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1929252/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.35.6.1116
Tagit:	Lisää tagi Ei tageja, Lisää ensimmäinen tagi!