Synthesis and antimicrobial evaluation of dirithromycin (AS-E 136; LY237216), a new macrolide antibiotic derived from erythromycin.

Dirithromycin is a 9-N-11-O-oxazine derivative which is formed by condensation of 9(S)-erythromycylamine with 2-(2-methoxyethoxy)acetaldehyde. Dirithromycin is hydrolyzed, either under acidic conditions or in vivo, to its major active metabolite, 9(S)-erythromycylamine. The antimicrobial spectrum of...

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Bibliografiske detaljer
Main Authors:	Counter, F T, Ensminger, P W, Preston, D A, Wu, C Y, Greene, J M, Felty-Duckworth, A M, Paschal, J W, Kirst, H A
Format:	Artigo
Sprog:	Inglês
Udgivet:	1991
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC284297/ https://ncbi.nlm.nih.gov/pubmed/1929252
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Synthesis and antimicrobial evaluation of dirithromycin (AS-E 136; LY237216), a new macrolide antibiotic derived from erythromycin.

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