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Differential Responses to SmD Autoantigen by Mice with HLA-DR and HLA-DQ Transgenes: Dominant Responses by HLA-DR3 Transgenic Mice with Diversification of Autoantibodies to snRNP, dsDNA and Nuclear Antigens
Anti-SmD autoantibodies are specific for systemic lupus erythematosus (SLE). In this investigation, the influence of HLA-D genes on immune responses to SmD was investigated. Mice with HLA-DR3, HLA-DR4, HLA-DQ0601, HLA-DQ0604 or HLA-DQ8 transgenes were immunized with recombinant SmD1 (SmD) and their...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2842881/ https://ncbi.nlm.nih.gov/pubmed/20007529 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902670 |
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