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“Unlicensed” Natural Killer cells dominate the response to cytomegalovirus infection

Natural killer (NK) cells expressing inhibitory receptors that bind to self-MHC class I are “licensed” or rendered functionally more responsive to stimulation, whereas “unlicensed” NK cells lacking receptors for self-MHC class I are hyporesponsive. Here we show that, contrary to the licensing hypoth...

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Autori principali: Orr, Mark T., Murphy, William J., Lanier, Lewis L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2842453/
https://ncbi.nlm.nih.gov/pubmed/20190757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1849
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