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Cellular pharmacology of 2',3'-dideoxy-2',3'-didehydrothymidine, a nucleoside analog active against human immunodeficiency virus.

2',3'-Dideoxy-2',3'-didehydrothymidine (D4T) is a thymidine nucleoside analog which has potent anti-human immunodeficiency virus activity in vitro. We have studied its metabolism in cells to assist in determining its mechanism of action. D4T is metabolized in cells to the mono-,...

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Bibliografische gegevens
Hoofdauteurs: Ho, H T, Hitchcock, M J
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1989
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC284243/
https://ncbi.nlm.nih.gov/pubmed/2764535
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