A salicylic acid-based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2)

The Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) plays a pivotal role in growth factor and cytokine signaling. Gain-of-function SHP2 mutations are associated with Noonan syndrome, various kinds of leukemias and solid tumors. Thus there is considerable interest in SHP2 as a...

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Autors principals: Zhang, Xian, He, Yantao, Liu, Sijiu, Yu, Zhihong, Jiang, Zhong-Xing, Yang, Zhenyun, Dong, Yuanshu, Nabinger, Sarah C., Wu, Li, Gunawan, Andrea M., Wang, Lina, Chan, Rebecca J., Zhang, Zhong-Yin
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2842125/
https://ncbi.nlm.nih.gov/pubmed/20170098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901645u
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