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Atomic details of near-transition state conformers for enzyme phosphoryl transfer revealed by [Formula: see text] rather than by phosphoranes

Prior evidence supporting the direct observation of phosphorane intermediates in enzymatic phosphoryl transfer reactions was based on the interpretation of electron density corresponding to trigonal species bridging the donor and acceptor atoms. Close examination of the crystalline state of β-phosph...

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Detalhes bibliográficos
Main Authors: Baxter, Nicola J., Bowler, Matthew W., Alizadeh, Tooba, Cliff, Matthew J., Hounslow, Andrea M., Wu, Bin, Berkowitz, David B., Williams, Nicholas H., Blackburn, G. Michael, Waltho, Jonathan P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2842025/
https://ncbi.nlm.nih.gov/pubmed/20164409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910333106
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