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Chemical Frustration in the Protein Folding Landscape: Grand Canonical Ensemble Simulations of Cytochrome c

A grand canonical formalism is developed to combine discrete simulations for chemically distinct species in equilibrium. Each simulation is based on a perturbed funneled landscape. The formalism is illustrated using the alkaline-induced transitions of cytochrome c as observed by FTIR spectroscopy an...

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Main Authors: Weinkam, Patrick, Romesberg, Floyd E., Wolynes, Peter G.
格式: Artigo
語言:Inglês
出版: 2009
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2842011/
https://ncbi.nlm.nih.gov/pubmed/19199810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi802293m
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