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A funneled energy landscape for cytochrome c directly predicts the sequential folding route inferred from hydrogen exchange experiments
Proteins fold through a variety of mechanisms. For a given protein, folding routes largely depend on the protein's stability and its native-state geometry, because the landscape is funneled. These ideas are corroborated for cytochrome c by using a coarse-grained topology-based model with a perf...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2005
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1194935/ https://ncbi.nlm.nih.gov/pubmed/16116080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505274102 |
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