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A funneled energy landscape for cytochrome c directly predicts the sequential folding route inferred from hydrogen exchange experiments

Proteins fold through a variety of mechanisms. For a given protein, folding routes largely depend on the protein's stability and its native-state geometry, because the landscape is funneled. These ideas are corroborated for cytochrome c by using a coarse-grained topology-based model with a perf...

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Bibliographic Details
Main Authors: Weinkam, Patrick, Zong, Chenghang, Wolynes, Peter G.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1194935/
https://ncbi.nlm.nih.gov/pubmed/16116080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505274102
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