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Origins of catalysis by computationally designed retroaldolase enzymes
We have investigated recently reported computationally designed retroaldolase enzymes with the goal of understanding the extent and the origins of their catalytic power. Direct comparison of the designed enzymes to primary amine catalysts in solution revealed a rate acceleration of 10(5)-fold for th...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2841948/ https://ncbi.nlm.nih.gov/pubmed/20194782 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913638107 |
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