Engineering cis-telomerase RNAs that add telomeric repeats to themselves

Telomerase is a ribonucleoprotein complex consisting of a protein reverse transcriptase (TERT) and an RNA subunit (TR). Telomerase normally adds telomeric DNA repeats to chromosome ends. Here, we engineer human and Tetrahymena cis-telomerase RNAs, each having a DNA primer covalently linked to its 3′...

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Bibliographic Details
Main Authors: Qiao, Feng, Goodrich, Karen J., Cech, Thomas R.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2010
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841905/
https://ncbi.nlm.nih.gov/pubmed/20194781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909366107
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