Ack1 Mediated AKT/PKB Tyrosine 176 Phosphorylation Regulates Its Activation

The AKT/PKB kinase is a key signaling component of one of the most frequently activated pathways in cancer and is a major target of cancer drug development. Most studies have focused on its activation by Receptor Tyrosine Kinase (RTK) mediated Phosphatidylinositol-3-OH kinase (PI3K) activation or lo...

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Hlavní autoři: Mahajan, Kiran, Coppola, Domenico, Challa, Sridevi, Fang, Bin, Chen, Y. Ann, Zhu, Weiwei, Lopez, Alexis S., Koomen, John, Engelman, Robert W., Rivera, Charlene, Muraoka-Cook, Rebecca S., Cheng, Jin Q., Schönbrunn, Ernst, Sebti, Said M., Earp, H. Shelton, Mahajan, Nupam P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2010
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841635/
https://ncbi.nlm.nih.gov/pubmed/20333297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009646
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