Xanthohumol Inhibits the Neuroendocrine Transcription Factor Achaete-Scute Complex-Like 1, Suppresses Proliferation and Induces Phosphorylated ERK1/2 in Medullary Thyroid Cancer

BACKGROUND: Achaete-Scute Complex-Like 1 (ASCL1) is a transcription factor important in the malignant development of Medullary Thyroid Cancer (MTC). Activation of Raf-1 signaling is associated with ASCL1 suppression and growth inhibition. Xanthohumol, a natural compound, has recently been shown to h...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Cook, Mackenzie R., Luo, Jie, Ndiaye, Mary, Chen, Herbert, Kunnimalaiyaan, Muthusamy
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841322/
https://ncbi.nlm.nih.gov/pubmed/20226902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.amjsurg.2009.08.034
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы