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Xanthohumol Inhibits the Neuroendocrine Transcription Factor Achaete-Scute Complex-Like 1, Suppresses Proliferation and Induces Phosphorylated ERK1/2 in Medullary Thyroid Cancer

BACKGROUND: Achaete-Scute Complex-Like 1 (ASCL1) is a transcription factor important in the malignant development of Medullary Thyroid Cancer (MTC). Activation of Raf-1 signaling is associated with ASCL1 suppression and growth inhibition. Xanthohumol, a natural compound, has recently been shown to h...

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Autori principali: Cook, Mackenzie R., Luo, Jie, Ndiaye, Mary, Chen, Herbert, Kunnimalaiyaan, Muthusamy
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841322/
https://ncbi.nlm.nih.gov/pubmed/20226902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.amjsurg.2009.08.034
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