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Synthesis of Functional Signaling Domains by Combinatorial Polymerization of Phosphorylation Motifs
The adaptor protein Cas contains a core substrate domain with multiple YXXP motifs that are phosphorylated by Src and other tyrosine kinases. Here, we used a synthetic strategy to determine the importance of the arrangement, spacing, and identity of the YXXP motifs. By polymerizing short DNA sequenc...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2841314/ https://ncbi.nlm.nih.gov/pubmed/19627099 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb900059f |
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