Hepatocyte IKKβ/NF-κB inhibits tumor promotion and progression by preventing oxidative stress driven STAT3 activation

The NF-κB activating kinase IKKβ suppresses early chemically-induced liver tumorigenesis by inhibiting hepatocyte death and compensatory proliferation. To study IKKβ’s role in late tumor promotion and progression, we developed a transplant system that allows initiated mouse hepatocytes to form hepat...

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Bibliografiske detaljer
Main Authors: He, Guobin, Yu, Guann-Yi, Temkin, Vladislav, Ogata, Hisanobu, Kuntzen, Christian, Sakurai, Toshiharu, Sieghart, Wolfgang, Peck-Radosavljevic, Markus, Leffert, Hyam L., Karin, Michael
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841312/
https://ncbi.nlm.nih.gov/pubmed/20227042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.12.048
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