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Targeted deletion of hepatocyte Ikkβ confers growth advantages

Mice lacking hepatocyte IKKβ (Ikkβ(Δhep)) are defective in TNFα-activation of hepatocellular transcription factor NF-κB, and highly susceptible to hepatotoxicity. Following diethylnitrosamine (DEN) exposure, Ikkβ(Δhep) mice develop more hepatocellular carcinoma (HCC) than control mice due partly to...

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Sonraí Bibleagrafaíochta
Main Authors: Koch, Katherine S., Maeda, Shin, He, Guobin, Karin, Michael, Leffert, Hyam L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2009
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663043/
https://ncbi.nlm.nih.gov/pubmed/19171122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.01.085
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