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Targeted deletion of hepatocyte Ikkβ confers growth advantages
Mice lacking hepatocyte IKKβ (Ikkβ(Δhep)) are defective in TNFα-activation of hepatocellular transcription factor NF-κB, and highly susceptible to hepatotoxicity. Following diethylnitrosamine (DEN) exposure, Ikkβ(Δhep) mice develop more hepatocellular carcinoma (HCC) than control mice due partly to...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2663043/ https://ncbi.nlm.nih.gov/pubmed/19171122 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.01.085 |
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