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Inference of RhoGAP/GTPase regulation using single-cell morphological data from a combinatorial RNAi screen

Biological networks are highly complex systems, consisting largely of enzymes that act as molecular switches to activate/inhibit downstream targets via post-translational modification. Computational techniques have been developed to perform signaling network inference using some high-throughput data...

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Autori principali: Nir, Oaz, Bakal, Chris, Perrimon, Norbert, Berger, Bonnie
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840989/
https://ncbi.nlm.nih.gov/pubmed/20144944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.100248.109
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