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Relationship between metronidazole metabolism and bactericidal activity.

It has been suggested that the microbicidal effect of metronidazole is mediated by an intermediate in nitro group reduction. We have found that the addition of Escherichia coli enhances the lethal effect of metronidazole on Bacillus fragilis and suggest that this intermediate may form in one bacteri...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Chrystal, E J, Koch, R L, McLafferty, M A, Goldman, P
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1980
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284050/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6255861/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.18.4.566
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