LXR modulation blocks prostaglandin E(2) production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model

Osteoarthritis (OA), the most common arthritic condition in humans, is characterized by the progressive degeneration of articular cartilage accompanied by chronic joint pain. Inflammatory mediators, such as cytokines and prostaglandin E(2) (PGE(2)) that are elevated in OA joints, play important role...

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Main Authors: Li, Ning, Rivéra-Bermúdez, Moisés A., Zhang, Mei, Tejada, Julio, Glasson, Sonya S., Collins-Racie, Lisa A., LaVallie, Edward R., Wang, Yihe, Chang, Ken C. N., Nagpal, Sunil, Morris, Elisabeth A., Flannery, Carl R., Yang, Zhiyong
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2010
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840473/
https://ncbi.nlm.nih.gov/pubmed/20133709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911377107
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