LXR modulation blocks prostaglandin E(2) production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model

Osteoarthritis (OA), the most common arthritic condition in humans, is characterized by the progressive degeneration of articular cartilage accompanied by chronic joint pain. Inflammatory mediators, such as cytokines and prostaglandin E(2) (PGE(2)) that are elevated in OA joints, play important role...

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Autori principali: Li, Ning, Rivéra-Bermúdez, Moisés A., Zhang, Mei, Tejada, Julio, Glasson, Sonya S., Collins-Racie, Lisa A., LaVallie, Edward R., Wang, Yihe, Chang, Ken C. N., Nagpal, Sunil, Morris, Elisabeth A., Flannery, Carl R., Yang, Zhiyong
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2010
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840473/
https://ncbi.nlm.nih.gov/pubmed/20133709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911377107
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