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Induced allostery in the directed evolution of an enantioselective Baeyer–Villiger monooxygenase
The molecular basis of allosteric effects, known to be caused by an effector docking to an enzyme at a site distal from the binding pocket, has been studied recently by applying directed evolution. Here, we utilize laboratory evolution in a different way, namely to induce allostery by introducing ap...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2840326/ https://ncbi.nlm.nih.gov/pubmed/20133612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911656107 |
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