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Lipid signaling in cytosolic phospholipase A(2)α–cyclooxygenase-2 cascade mediates cerebellar long-term depression and motor learning
In this study, we show the crucial roles of lipid signaling in long-term depression (LTD), that is, synaptic plasticity prevailing in cerebellar Purkinje cells. In mouse brain slices, we found that cPLA(2)α knockout blocked LTD induction, which was rescued by replenishing arachidonic acid (AA) or pr...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2840314/ https://ncbi.nlm.nih.gov/pubmed/20133605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0915020107 |
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