Lipid signaling in cytosolic phospholipase A(2)α–cyclooxygenase-2 cascade mediates cerebellar long-term depression and motor learning

In this study, we show the crucial roles of lipid signaling in long-term depression (LTD), that is, synaptic plasticity prevailing in cerebellar Purkinje cells. In mouse brain slices, we found that cPLA(2)α knockout blocked LTD induction, which was rescued by replenishing arachidonic acid (AA) or pr...

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Detalhes bibliográficos
Main Authors: Le, Tung Dinh, Shirai, Yoshinori, Okamoto, Takehito, Tatsukawa, Tetsuya, Nagao, Soichi, Shimizu, Takao, Ito, Masao
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840314/
https://ncbi.nlm.nih.gov/pubmed/20133605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0915020107
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