Lipid signaling in cytosolic phospholipase A(2)α–cyclooxygenase-2 cascade mediates cerebellar long-term depression and motor learning

In this study, we show the crucial roles of lipid signaling in long-term depression (LTD), that is, synaptic plasticity prevailing in cerebellar Purkinje cells. In mouse brain slices, we found that cPLA(2)α knockout blocked LTD induction, which was rescued by replenishing arachidonic acid (AA) or pr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Le, Tung Dinh, Shirai, Yoshinori, Okamoto, Takehito, Tatsukawa, Tetsuya, Nagao, Soichi, Shimizu, Takao, Ito, Masao
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2010
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840314/
https://ncbi.nlm.nih.gov/pubmed/20133605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0915020107
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